| 8/28/2010 | Cumberlands KY 27 vs McKendree Bearcats 34 (Dyersburg TN) | |
| 9/11/2010 | Cumberlands KY 55 @ Virginia-Wise Highland Cavaliers 10 | † |
| 9/18/2010 | Georgetown KY Tigers 58 @ Cumberlands KY 40 | † |
| 9/25/2010 | Cumberlands KY 35 @ Bethel TN Wildcats 33 | † |
| 10/2/2010 | Union KY Bulldogs 21 @ Cumberlands KY 35 | † |
| 10/16/2010 | Campbellsville Tigers 28 @ Cumberlands KY 34 | † |
| 10/23/2010 | Cumberlands KY @ Shorter Hawks (Kennesaw GA) | † |
| 10/30/2010 | Cumberlands KY 21 @ Belhaven Blazers 24 | † |
| 11/6/2010 | Faulkner Eagles 7 @ Cumberlands KY 79 | † |
| 11/13/2010 | Cumberland TN Bulldogs 27 @ Cumberlands KY 52 | † |
| 11/20/2010 | Cumberlands KY 19 @ St Xavier Cougars 66 |