| 9/4/2010 | Wesley Wolverines 34 @ Christopher Newport 6 | |
| 9/11/2010 | Christopher Newport 10 @ Salisbury Seagulls 58 | |
| 9/18/2010 | Christopher Newport 31 @ Frostburg State Bobcats 33 | |
| 10/2/2010 | Christopher Newport 28 @ Shenandoah Hornets 13 | † |
| 10/9/2010 | Averett Cougars 17 @ Christopher Newport 9 | † |
| 10/16/2010 | Christopher Newport 23 @ North Carolina Wesleyan Battling Bishops 15 | † |
| 10/23/2010 | Greensboro Pride 7 @ Christopher Newport 37 | † |
| 10/30/2010 | Ferrum Panthers 21 @ Christopher Newport 27 | † |
| 11/6/2010 | Christopher Newport 42 @ Maryville Saints 10 | † |
| 11/13/2010 | Methodist Monarchs 10 @ Christopher Newport 49 | † |
| 11/20/2010 | Christopher Newport 7 @ Mary Hardin-Baylor Crusaders 59 (D3 Playoffs Round 1) |