| 9/4/2010 | Hampden-Sydney 45 @ Averett Cougars 30 | |
| 9/11/2010 | North Carolina Wesleyan Battling Bishops 19 @ Hampden-Sydney 21 | |
| 9/18/2010 | Sewanee Tigers 0 @ Hampden-Sydney 38 | |
| 9/25/2010 | Hampden-Sydney 32 @ Salisbury Seagulls 28 | |
| 10/2/2010 | Hampden-Sydney 35 @ Catholic Cardinals 27 | † |
| 10/9/2010 | Hampden-Sydney 24 @ Bridgewater VA Eagles 17 | † |
| 10/16/2010 | Emory & Henry Wasps 10 @ Hampden-Sydney 48 | † |
| 10/30/2010 | Guilford Quakers 20 @ Hampden-Sydney 49 | † |
| 11/6/2010 | Hampden-Sydney 27 @ Washington and Lee Generals 38 | † |
| 11/13/2010 | Randolph-Macon Yellow Jackets 28 @ Hampden-Sydney 31 | † |
| 11/20/2010 | Montclair State Red Hawks 16 @ Hampden-Sydney 14 (D3 Playoffs Round 1) |