| 9/4/2010 | Maryville 3 @ Huntingdon AL Hawks 54 | |
| 9/11/2010 | Centre Praying Colonels 35 @ Maryville 0 | |
| 9/18/2010 | LaGrange Panthers 17 @ Maryville 20 3OT | |
| 10/2/2010 | Maryville 14 @ Methodist Monarchs 17 | † |
| 10/9/2010 | Shenandoah Hornets 7 @ Maryville 6 | † |
| 10/16/2010 | Maryville 21 @ Averett Cougars 14 | † |
| 10/23/2010 | North Carolina Wesleyan Battling Bishops 34 @ Maryville 16 | † |
| 10/30/2010 | Maryville 40 @ Greensboro Pride 6 | † |
| 11/6/2010 | Christopher Newport Captains 42 @ Maryville 10 | † |
| 11/13/2010 | Maryville 23 @ Ferrum Panthers 21 | † |