| 9/4/2010 | LaGrange 19 @ Birmingham-Southern Panthers 28 | |
| 9/11/2010 | Millsaps Majors 21 @ LaGrange 27 | |
| 9/18/2010 | LaGrange 17 @ Maryville Saints 20 3OT | |
| 9/25/2010 | LaGrange 24 @ North Carolina Wesleyan Battling Bishops 35 | |
| 10/2/2010 | LaGrange 42 @ Rhodes Lynx 28 | |
| 10/9/2010 | LaGrange 7 @ Trine Thunder 51 | |
| 10/16/2010 | North Greenville Crusaders 55 @ LaGrange 27 | |
| 10/30/2010 | Apprentice Ship Builders 14 @ LaGrange 21 | |
| 11/6/2010 | Huntingdon AL Hawks 35 @ LaGrange 28 | † |
| 11/13/2010 | LaGrange 7 @ Centre Praying Colonels 48 |