| 9/4/2010 | Randolph-Macon 54 @ Methodist Monarchs 14 | |
| 9/11/2010 | Johns Hopkins Blue Jays 37 @ Randolph-Macon 41 | |
| 9/18/2010 | Shenandoah Hornets 14 @ Randolph-Macon 42 | |
| 9/25/2010 | Frostburg State Bobcats 14 @ Randolph-Macon 48 | |
| 10/2/2010 | Randolph-Macon 34 @ Emory & Henry Wasps 22 | † |
| 10/9/2010 | Catholic Cardinals 28 @ Randolph-Macon 56 | † |
| 10/16/2010 | Randolph-Macon 28 @ Washington and Lee Generals 42 | † |
| 10/23/2010 | Guilford Quakers 21 @ Randolph-Macon 59 | † |
| 11/6/2010 | Bridgewater VA Eagles 31 @ Randolph-Macon 26 | † |
| 11/13/2010 | Randolph-Macon 28 @ Hampden-Sydney Tigers 31 | † |