| 9/4/2010 | Emory & Henry 23 @ Ferrum Panthers 17 2OT | |
| 9/11/2010 | Emory & Henry 28 @ Greensboro Pride 6 | |
| 9/18/2010 | Virginia-Wise Highland Cavaliers 10 @ Emory & Henry 20 | |
| 9/25/2010 | Methodist Monarchs 6 @ Emory & Henry 49 | |
| 10/2/2010 | Randolph-Macon Yellow Jackets 34 @ Emory & Henry 22 | † |
| 10/9/2010 | Emory & Henry 24 @ Washington and Lee Generals 45 | † |
| 10/16/2010 | Emory & Henry 10 @ Hampden-Sydney Tigers 48 | † |
| 10/23/2010 | Catholic Cardinals 33 @ Emory & Henry 31 | † |
| 10/30/2010 | Emory & Henry 10 @ Bridgewater VA Eagles 24 | † |
| 11/13/2010 | Guilford Quakers 3 @ Emory & Henry 27 | † |