| 9/4/2010 | Greensboro Pride 17 @ Guilford 15 | |
| 9/11/2010 | Methodist Monarchs 26 @ Guilford 21 | |
| 9/18/2010 | Guilford 9 @ Averett Cougars 45 | |
| 10/2/2010 | Washington and Lee Generals 55 @ Guilford 29 | † |
| 10/9/2010 | Guilford 21 @ Southern Virginia Knights 36 | |
| 10/16/2010 | Bridgewater VA Eagles 56 @ Guilford 27 | † |
| 10/23/2010 | Guilford 21 @ Randolph-Macon Yellow Jackets 59 | † |
| 10/30/2010 | Guilford 20 @ Hampden-Sydney Tigers 49 | † |
| 11/6/2010 | Catholic Cardinals 23 @ Guilford 22 | † |
| 11/13/2010 | Guilford 3 @ Emory & Henry Wasps 27 | † |