| 9/4/2010 | Carnegie Mellon 28 @ Grove City Wolverines 21 | |
| 9/11/2010 | Carnegie Mellon 27 @ Allegheny Gators 34 | |
| 9/18/2010 | Hobart Statesmen 35 @ Carnegie Mellon 21 | |
| 9/25/2010 | Kenyon Lords 10 @ Carnegie Mellon 17 | |
| 10/2/2010 | Hiram Terriers 31 @ Carnegie Mellon 62 | |
| 10/9/2010 | Carnegie Mellon 35 @ Ohio Wesleyan Battling Bishops 23 | |
| 10/23/2010 | Wittenberg Tigers 27 @ Carnegie Mellon 21 1OT | |
| 10/30/2010 | Carnegie Mellon 13 @ Washington U Bears 20 1OT | † |
| 11/6/2010 | Chicago Maroons 61 @ Carnegie Mellon 22 | † |
| 11/13/2010 | Carnegie Mellon 0 @ Case Western Reserve Spartans 28 | † |