| 9/4/2010 | Gettysburg Bullets 42 @ Lebanon Valley 28 | |
| 9/11/2010 | Grove City Wolverines 17 @ Lebanon Valley 14 | |
| 9/18/2010 | Moravian Greyhounds 6 @ Lebanon Valley 21 | |
| 10/2/2010 | Lebanon Valley 6 @ Delaware Valley Aggies 38 | † |
| 10/9/2010 | Wilkes Colonels 35 @ Lebanon Valley 28 1OT | † |
| 10/16/2010 | Fairleigh Dickinson-Florham Devils 21 @ Lebanon Valley 33 | † |
| 10/23/2010 | Lebanon Valley 21 @ King's Monarchs 19 | † |
| 10/30/2010 | Widener Pride 38 @ Lebanon Valley 42 | † |
| 11/6/2010 | Lebanon Valley 28 @ Lycoming Warriors 14 | † |
| 11/13/2010 | Albright Lions 13 @ Lebanon Valley 28 | † |
| 11/20/2010 | Lebanon Valley 14 @ Johns Hopkins Blue Jays 44 (ECAC South Atlantic Bowl) |