| 9/4/2010 | Maryville Saints 3 @ Huntingdon AL 54 | |
| 9/11/2010 | Huntingdon AL 62 @ Louisiana College Wildcats 56 | |
| 9/18/2010 | Huntingdon AL 42 @ Faulkner Eagles 10 | |
| 9/25/2010 | Birmingham-Southern Panthers 35 @ Huntingdon AL 20 | |
| 10/2/2010 | Wesley Wolverines 61 @ Huntingdon AL 28 | |
| 10/9/2010 | Huntingdon AL 19 @ Millsaps Majors 35 | |
| 10/16/2010 | Huntingdon AL 21 @ Salisbury Seagulls 45 | |
| 10/23/2010 | Huntingdon AL 35 @ Webber International Warriors 23 | |
| 10/30/2010 | Trinity TX Tigers 30 @ Huntingdon AL 56 | |
| 11/6/2010 | Huntingdon AL 35 @ LaGrange Panthers 28 | † |