| 9/4/2010 | Hanover Panthers 28 @ Centre 27 1OT | |
| 9/11/2010 | Centre 35 @ Maryville Saints 0 | |
| 9/18/2010 | DePauw Tigers 21 @ Centre 16 | † |
| 9/25/2010 | Centre 42 @ Austin Kangaroos 40 | † |
| 10/2/2010 | Centre 64 @ Sewanee Tigers 13 | † |
| 10/9/2010 | Birmingham-Southern Panthers 28 @ Centre 35 | † |
| 10/23/2010 | Millsaps Majors 30 @ Centre 18 | † |
| 10/30/2010 | Centre 31 @ Rhodes Lynx 38 | † |
| 11/6/2010 | Trinity TX Tigers 7 @ Centre 26 | † |
| 11/13/2010 | LaGrange Panthers 7 @ Centre 48 |