| 8/28/2010 | Shepherd 35 @ Shippensburg Red Raiders 27 | |
| 9/11/2010 | St Joseph's Pumas 0 @ Shepherd 55 | |
| 9/18/2010 | Fairmont State Falcons 16 @ Shepherd 19 | † |
| 9/25/2010 | Shepherd 46 @ Seton Hill Griffons 17 | † |
| 10/2/2010 | Shepherd 28 @ Charleston WV Golden Eagles 13 | † |
| 10/9/2010 | Concord Mountain Lions 35 @ Shepherd 49 | † |
| 10/16/2010 | West Virginia Wesleyan Bobcats 26 @ Shepherd 37 | † |
| 10/23/2010 | Shepherd 53 @ West Liberty Hilltoppers 38 | † |
| 10/30/2010 | Shepherd 56 @ West Virginia State Yellow Jackets 19 | † |
| 11/13/2010 | Glenville State Pioneers 28 @ Shepherd 24 | † |
| 11/20/2010 | Shaw Bears 6 @ Shepherd 40 | |
| 11/27/2010 | Shepherd 41 @ Kutztown Golden Bears 34 | |
| 12/4/2010 | Shepherd 49 @ Mercyhurst Lakers 14 | |
| 12/11/2010 | Shepherd 17 @ Delta State Statesmen 29 |