| 8/28/2010 | Charleston WV 12 @ Tusculum Pioneers 24 | |
| 9/4/2010 | Mars Hill Lions 20 @ Charleston WV 42 | |
| 9/18/2010 | West Virginia State Yellow Jackets 0 @ Charleston WV 42 | † |
| 9/25/2010 | Charleston WV 28 @ Concord Mountain Lions 37 | † |
| 10/2/2010 | Shepherd Rams 28 @ Charleston WV 13 | † |
| 10/9/2010 | Fairmont State Falcons 27 @ Charleston WV 35 | † |
| 10/16/2010 | Seton Hill Griffons 20 @ Charleston WV 24 | † |
| 10/23/2010 | Charleston WV 44 @ Urbana Blue Knights 34 | |
| 10/30/2010 | Charleston WV 23 @ West Liberty Hilltoppers 37 | † |
| 11/6/2010 | Charleston WV 44 @ Glenville State Pioneers 16 | † |
| 11/13/2010 | Charleston WV 21 @ West Virginia Wesleyan Bobcats 41 | † |