| 8/28/2010 | Mercyhurst 23 @ Notre Dame OH Falcons 0 | |
| 9/11/2010 | Mercyhurst 14 @ Kutztown Golden Bears 35 | † |
| 9/18/2010 | Mercyhurst 28 @ C W Post Pioneers 20 | † |
| 9/25/2010 | Lock Haven Bald Eagles 0 @ Mercyhurst 41 | † |
| 10/2/2010 | Mercyhurst 10 @ Gannon Golden Knights 14 | † |
| 10/9/2010 | Mercyhurst 28 @ Indiana PA Crimson Hawks 27 | † |
| 10/16/2010 | Mercyhurst 22 @ Edinboro Scots 21 1OT | † |
| 10/23/2010 | California PA Vulcans 21 @ Mercyhurst 31 | † |
| 10/30/2010 | Slippery Rock Rockets 13 @ Mercyhurst 21 | † |
| 11/6/2010 | Clarion Golden Eagles 14 @ Mercyhurst 38 | † |
| 11/13/2010 | Shippensburg Red Raiders 37 @ Mercyhurst 56 | † |
| 11/27/2010 | Bloomsburg Huskies 14 @ Mercyhurst 28 | † |
| 12/4/2010 | Shepherd Rams 49 @ Mercyhurst 14 |