| 9/2/2010 | West Virginia Tech Golden Bears 10 @ Glenville State 44 | |
| 9/11/2010 | North Alabama Lions 54 @ Glenville State 10 | |
| 9/18/2010 | Seton Hill Griffons 28 @ Glenville State 38 | † |
| 9/25/2010 | Fairmont State Falcons 14 @ Glenville State 17 1OT | † |
| 10/2/2010 | UNC Pembroke Braves 28 @ Glenville State 14 | |
| 10/9/2010 | Glenville State 21 @ West Liberty Hilltoppers 47 | † |
| 10/16/2010 | Glenville State 14 @ Concord Mountain Lions 49 | † |
| 10/23/2010 | West Virginia State Yellow Jackets 27 @ Glenville State 42 | † |
| 10/30/2010 | Glenville State 24 @ West Virginia Wesleyan Bobcats 31 | † |
| 11/6/2010 | Charleston WV Golden Eagles 44 @ Glenville State 16 | † |
| 11/13/2010 | Glenville State 28 @ Shepherd Rams 24 | † |