| 9/4/2010 | Edinboro Scots 20 @ West Liberty 19 | |
| 9/11/2010 | West Liberty 49 @ Southern Connecticut Owls 35 | |
| 9/25/2010 | West Virginia Wesleyan Bobcats 43 @ West Liberty 41 | † |
| 9/30/2010 | West Liberty 43 @ Fairmont State Falcons 23 | † |
| 10/9/2010 | Glenville State Pioneers 21 @ West Liberty 47 | † |
| 10/16/2010 | West Liberty 48 @ West Virginia State Yellow Jackets 26 | † |
| 10/23/2010 | Shepherd Rams 53 @ West Liberty 38 | † |
| 10/30/2010 | Charleston WV Golden Eagles 23 @ West Liberty 37 | † |
| 11/6/2010 | West Liberty 82 @ Seton Hill Griffons 36 | † |
| 11/13/2010 | West Liberty 56 @ Concord Mountain Lions 33 | † |