| 9/4/2010 | West Virginia State 14 vs Central State Marauders 34 (Dayton OH) | |
| 9/11/2010 | West Virginia State 21 @ Virginia State Trojans 34 | |
| 9/18/2010 | West Virginia State 0 @ Charleston WV Golden Eagles 42 | † |
| 10/2/2010 | Concord Mountain Lions 42 @ West Virginia State 18 | † |
| 10/9/2010 | West Virginia State 20 @ Seton Hill Griffons 48 | † |
| 10/16/2010 | West Liberty Hilltoppers 48 @ West Virginia State 26 | † |
| 10/23/2010 | West Virginia State 27 @ Glenville State Pioneers 42 | † |
| 10/30/2010 | Shepherd Rams 56 @ West Virginia State 19 | † |
| 11/6/2010 | West Virginia Wesleyan Bobcats 50 @ West Virginia State 28 | † |
| 11/13/2010 | West Virginia State 38 @ Fairmont State Falcons 63 | † |