| 8/28/2010 | St Paul's Fighting Tigers 28 @ West Virginia Wesleyan 35 | |
| 9/4/2010 | Urbana Blue Knights 14 @ West Virginia Wesleyan 17 | |
| 9/18/2010 | Concord Mountain Lions 13 @ West Virginia Wesleyan 20 | † |
| 9/25/2010 | West Virginia Wesleyan 43 @ West Liberty Hilltoppers 41 | † |
| 10/2/2010 | Seton Hill Griffons 16 @ West Virginia Wesleyan 37 | † |
| 10/9/2010 | West Virginia Wesleyan 58 @ Livingstone Blue Bears 3 | |
| 10/16/2010 | West Virginia Wesleyan 26 @ Shepherd Rams 37 | † |
| 10/23/2010 | West Virginia Wesleyan 14 @ Fairmont State Falcons 45 | † |
| 10/30/2010 | Glenville State Pioneers 24 @ West Virginia Wesleyan 31 | † |
| 11/6/2010 | West Virginia Wesleyan 50 @ West Virginia State Yellow Jackets 28 | † |
| 11/13/2010 | Charleston WV Golden Eagles 21 @ West Virginia Wesleyan 41 | † |