| 9/4/2010 | Saint Anselm Hawks 0 @ Kutztown 41 | |
| 9/11/2010 | Mercyhurst Lakers 14 @ Kutztown 35 | † |
| 9/18/2010 | Kutztown 38 @ Lock Haven Bald Eagles 13 | † |
| 9/25/2010 | Kutztown 52 @ Cheyney Wolves 14 | † |
| 10/2/2010 | Shippensburg Red Raiders 24 @ Kutztown 33 | † |
| 10/9/2010 | Kutztown 38 @ East Stroudsburg Warriors 31 | † |
| 10/16/2010 | Millersville Marauders 28 @ Kutztown 38 | † |
| 10/23/2010 | C W Post Pioneers 48 @ Kutztown 50 | † |
| 10/30/2010 | West Chester Golden Rams 23 @ Kutztown 45 | † |
| 11/6/2010 | Kutztown 35 @ Bloomsburg Huskies 61 | † |
| 11/13/2010 | Kutztown 27 @ Gannon Golden Knights 24 | † |
| 11/27/2010 | Shepherd Rams 41 @ Kutztown 34 |