| 9/2/2010 | West Texas A&M 31 @ Grand Valley State Lakers 34 | |
| 9/11/2010 | West Texas A&M 77 @ Southwestern Oklahoma State Bulldogs 14 | † |
| 9/18/2010 | Southeastern Oklahoma State Savage Storm 17 @ West Texas A&M 41 | † |
| 9/25/2010 | West Texas A&M 37 @ Angelo State Rams 27 | † |
| 10/2/2010 | West Texas A&M 34 @ Northeastern State Riverhawks 22 | † |
| 10/9/2010 | Tarleton State Texans 17 @ West Texas A&M 48 | † |
| 10/16/2010 | West Texas A&M 24 @ Texas A&M-Kingsville Javelinas 28 | † |
| 10/23/2010 | Midwestern State Mustangs 29 @ West Texas A&M 42 | † |
| 10/30/2010 | West Texas A&M 49 @ Incarnate Word Cardinals 10 | † |
| 11/6/2010 | Abilene Christian Wildcats 41 @ West Texas A&M 34 | † |
| 11/13/2010 | East Central Tigers 21 @ West Texas A&M 52 | † |
| 11/20/2010 | West Texas A&M 35 @ Central Missouri Mules 55 |