| 9/2/2010 | Texas A&M-Kingsville 16 @ Northwest Missouri State Bearcats 7 | |
| 9/11/2010 | Texas A&M-Kingsville 20 @ East Central Tigers 7 | † |
| 9/18/2010 | Texas A&M-Commerce Lions 0 @ Texas A&M-Kingsville 21 | † |
| 9/25/2010 | Texas A&M-Kingsville 37 @ Incarnate Word Cardinals 9 | † |
| 10/2/2010 | Abilene Christian Wildcats 31 @ Texas A&M-Kingsville 24 | † |
| 10/9/2010 | Texas A&M-Kingsville 28 @ Angelo State Rams 21 | † |
| 10/16/2010 | West Texas A&M Buffaloes 24 @ Texas A&M-Kingsville 28 | † |
| 10/23/2010 | Texas A&M-Kingsville 13 @ Tarleton State Texans 10 | † |
| 10/30/2010 | Texas A&M-Kingsville 56 @ Southwestern Oklahoma State Bulldogs 17 | † |
| 11/6/2010 | Midwestern State Mustangs 7 @ Texas A&M-Kingsville 27 | † |
| 11/13/2010 | Southeastern Oklahoma State Savage Storm 24 @ Texas A&M-Kingsville 38 | † |
| 11/27/2010 | Northwest Missouri State Bearcats 35 @ Texas A&M-Kingsville 31 |