| 8/26/2010 | Southeastern Oklahoma State 13 @ Henderson State Reddies 44 | |
| 9/11/2010 | Incarnate Word Cardinals 19 @ Southeastern Oklahoma State 38 | † |
| 9/18/2010 | Southeastern Oklahoma State 17 @ West Texas A&M Buffaloes 41 | † |
| 9/25/2010 | Northeastern State Riverhawks 26 @ Southeastern Oklahoma State 24 | † |
| 10/2/2010 | Southeastern Oklahoma State 14 @ Texas A&M-Commerce Lions 19 | † |
| 10/9/2010 | Southwestern Oklahoma State Bulldogs 35 @ Southeastern Oklahoma State 42 | † |
| 10/16/2010 | Southeastern Oklahoma State 56 @ Central Oklahoma Bronchos 55 1OT | † |
| 10/23/2010 | East Central Tigers 20 @ Southeastern Oklahoma State 19 | † |
| 10/30/2010 | Southeastern Oklahoma State 20 @ Eastern New Mexico Greyhounds 55 | † |
| 11/6/2010 | Angelo State Rams 40 @ Southeastern Oklahoma State 33 | † |
| 11/13/2010 | Southeastern Oklahoma State 24 @ Texas A&M-Kingsville Javelinas 38 | † |