| 8/26/2010 | Southeastern Oklahoma State @ Henderson State | |
| 8/26/2010 | Emporia State @ Southwestern Oklahoma State | |
| 8/28/2010 | Pittsburg State @ Central Oklahoma | |
| 8/28/2010 | Southern Nazarene @ Eastern New Mexico | |
| 8/28/2010 | Langston @ Incarnate Word | |
| 9/2/2010 | West Texas A&M @ Grand Valley State | |
| 9/2/2010 | Midwestern State @ New Mexico Highlands | |
| 9/2/2010 | Texas A&M-Kingsville @ Northwest Missouri State | |
| 9/2/2010 | Northeastern State @ Tarleton State | † |
| 9/4/2010 | Eastern New Mexico @ Angelo State | † |
| 9/4/2010 | East Central @ Fort Hays State | |
| 9/4/2010 | Upper Iowa @ Texas A&M-Commerce | |
| 9/4/2010 | Abilene Christian @ Washburn | |
| 9/11/2010 | Tarleton State @ Central Oklahoma | † |
| 9/11/2010 | Texas A&M-Kingsville @ East Central | † |
| 9/11/2010 | Midwestern State @ Eastern New Mexico | † |
| 9/11/2010 | Abilene Christian @ Northeastern State | † |
| 9/11/2010 | Incarnate Word @ Southeastern Oklahoma State | † |
| 9/11/2010 | West Texas A&M @ Southwestern Oklahoma State | † |
| 9/11/2010 | Angelo State vs Texas A&M-Commerce | † |
| 9/18/2010 | East Central @ Abilene Christian | † |
| 9/18/2010 | Central Oklahoma @ Incarnate Word | † |
| 9/18/2010 | Southwestern Oklahoma State @ Midwestern State | † |
| 9/18/2010 | Northeastern State @ North Dakota | |
| 9/18/2010 | Tarleton State @ Northwestern State | |
| 9/18/2010 | Texas A&M-Commerce @ Texas A&M-Kingsville | † |
| 9/18/2010 | Southeastern Oklahoma State @ West Texas A&M | † |
| 9/25/2010 | Tarleton State @ Abilene Christian | † |
| 9/25/2010 | West Texas A&M @ Angelo State | † |
| 9/25/2010 | Midwestern State @ Central Oklahoma | † |
| 9/25/2010 | Southwestern Oklahoma State @ East Central | † |
| 9/25/2010 | Texas A&M-Commerce @ Eastern New Mexico | † |
| 9/25/2010 | Texas A&M-Kingsville @ Incarnate Word | † |
| 9/25/2010 | Northeastern State @ Southeastern Oklahoma State | † |
| 10/2/2010 | East Central @ Central Oklahoma | † |
| 10/2/2010 | Incarnate Word @ Midwestern State | † |
| 10/2/2010 | West Texas A&M @ Northeastern State | † |
| 10/2/2010 | Eastern New Mexico @ Southwestern Oklahoma State | † |
| 10/2/2010 | Southeastern Oklahoma State @ Texas A&M-Commerce | † |
| 10/2/2010 | Abilene Christian @ Texas A&M-Kingsville | † |
| 10/2/2010 | Angelo State @ Tarleton State | † |
| 10/9/2010 | Midwestern State @ Abilene Christian | † |
| 10/9/2010 | Texas A&M-Kingsville @ Angelo State | † |
| 10/9/2010 | Incarnate Word @ East Central | † |
| 10/9/2010 | Central Oklahoma @ Eastern New Mexico | † |
| 10/9/2010 | Texas A&M-Commerce @ Northeastern State | † |
| 10/9/2010 | Southwestern Oklahoma State @ Southeastern Oklahoma State | † |
| 10/9/2010 | Tarleton State @ West Texas A&M | † |
| 10/16/2010 | Southeastern Oklahoma State @ Central Oklahoma | † |
| 10/16/2010 | Eastern New Mexico @ East Central | † |
| 10/16/2010 | Abilene Christian @ Incarnate Word | † |
| 10/16/2010 | Angelo State @ Midwestern State | † |
| 10/16/2010 | Northeastern State @ Southwestern Oklahoma State | † |
| 10/16/2010 | Tarleton State @ Texas A&M-Commerce | † |
| 10/16/2010 | West Texas A&M @ Texas A&M-Kingsville | † |
| 10/23/2010 | Incarnate Word @ Angelo State | † |
| 10/23/2010 | Abilene Christian @ Eastern New Mexico | † |
| 10/23/2010 | Central Oklahoma @ Northeastern State | † |
| 10/23/2010 | East Central @ Southeastern Oklahoma State | † |
| 10/23/2010 | Southwestern Oklahoma State @ Texas A&M-Commerce | † |
| 10/23/2010 | Texas A&M-Kingsville @ Tarleton State | † |
| 10/23/2010 | Midwestern State @ West Texas A&M | † |
| 10/30/2010 | Angelo State @ Abilene Christian | † |
| 10/30/2010 | Texas A&M-Commerce @ Central Oklahoma | † |
| 10/30/2010 | Northeastern State @ East Central | † |
| 10/30/2010 | Southeastern Oklahoma State @ Eastern New Mexico | † |
| 10/30/2010 | West Texas A&M @ Incarnate Word | † |
| 10/30/2010 | Tarleton State @ Midwestern State | † |
| 10/30/2010 | Texas A&M-Kingsville @ Southwestern Oklahoma State | † |
| 11/6/2010 | Eastern New Mexico @ Northeastern State | † |
| 11/6/2010 | Angelo State @ Southeastern Oklahoma State | † |
| 11/6/2010 | Central Oklahoma @ Southwestern Oklahoma State | † |
| 11/6/2010 | East Central @ Texas A&M-Commerce | † |
| 11/6/2010 | Midwestern State @ Texas A&M-Kingsville | † |
| 11/6/2010 | Incarnate Word @ Tarleton State | † |
| 11/6/2010 | Abilene Christian @ West Texas A&M | † |
| 11/13/2010 | Southwestern Oklahoma State @ Abilene Christian | † |
| 11/13/2010 | Central Oklahoma @ Angelo State | † |
| 11/13/2010 | Texas A&M-Commerce @ Incarnate Word | † |
| 11/13/2010 | Northeastern State @ Midwestern State | † |
| 11/13/2010 | Southeastern Oklahoma State @ Texas A&M-Kingsville | † |
| 11/13/2010 | Eastern New Mexico @ Tarleton State | † |
| 11/13/2010 | East Central @ West Texas A&M | † |