| 9/2/2010 | Northeastern State 31 @ Tarleton State Texans 23 | † |
| 9/11/2010 | Abilene Christian Wildcats 43 @ Northeastern State 13 | † |
| 9/18/2010 | Northeastern State 14 @ North Dakota Sioux 55 | |
| 9/25/2010 | Northeastern State 26 @ Southeastern Oklahoma State Savage Storm 24 | † |
| 10/2/2010 | West Texas A&M Buffaloes 34 @ Northeastern State 22 | † |
| 10/9/2010 | Texas A&M-Commerce Lions 7 @ Northeastern State 38 | † |
| 10/16/2010 | Northeastern State 20 @ Southwestern Oklahoma State Bulldogs 10 | † |
| 10/23/2010 | Central Oklahoma Bronchos 28 @ Northeastern State 39 | † |
| 10/30/2010 | Northeastern State 21 @ East Central Tigers 48 | † |
| 11/6/2010 | Eastern New Mexico Greyhounds 40 @ Northeastern State 43 | † |
| 11/13/2010 | Northeastern State 8 @ Midwestern State Mustangs 28 | † |