| 9/4/2010 | Abilene Christian 34 @ Washburn Ichabods 26 | |
| 9/11/2010 | Abilene Christian 43 @ Northeastern State Riverhawks 13 | † |
| 9/18/2010 | East Central Tigers 7 @ Abilene Christian 47 | † |
| 9/25/2010 | Tarleton State Texans 3 @ Abilene Christian 65 | † |
| 10/2/2010 | Abilene Christian 31 @ Texas A&M-Kingsville Javelinas 24 | † |
| 10/9/2010 | Midwestern State Mustangs 28 @ Abilene Christian 31 | † |
| 10/16/2010 | Abilene Christian 54 @ Incarnate Word Cardinals 17 | † |
| 10/23/2010 | Abilene Christian 53 @ Eastern New Mexico Greyhounds 14 | † |
| 10/30/2010 | Angelo State Rams 20 @ Abilene Christian 33 | † |
| 11/6/2010 | Abilene Christian 41 @ West Texas A&M Buffaloes 34 | † |
| 11/13/2010 | Southwestern Oklahoma State Bulldogs 17 @ Abilene Christian 47 | † |
| 11/27/2010 | Central Missouri Mules 55 @ Abilene Christian 41 |