| 9/2/2010 | West Texas A&M Buffaloes 31 @ Grand Valley State 34 | |
| 9/11/2010 | Hillsdale Chargers 41 @ Grand Valley State 44 | † |
| 9/18/2010 | Indianapolis Greyhounds 31 @ Grand Valley State 38 | † |
| 9/25/2010 | Grand Valley State 35 @ Findlay Oilers 7 | † |
| 10/2/2010 | Grand Valley State 71 @ Tiffin Dragons 10 | † |
| 10/9/2010 | Northern Michigan Wildcats 7 @ Grand Valley State 28 | † |
| 10/16/2010 | Lake Erie Storm 23 @ Grand Valley State 57 | † |
| 10/23/2010 | Grand Valley State 41 @ Ferris State Bulldogs 0 | † |
| 10/30/2010 | Grand Valley State 17 @ Michigan Tech Huskies 20 | † |
| 11/6/2010 | Northwood Timberwolves 21 @ Grand Valley State 35 | † |
| 11/13/2010 | Grand Valley State 28 @ Saginaw Valley State Cardinals 7 | † |
| 11/20/2010 | Colorado Mines Orediggers 13 @ Grand Valley State 35 | |
| 11/27/2010 | Grand Valley State 6 @ Augustana SD Vikings 38 |