| 9/4/2010 | East Central 23 @ Fort Hays State Tigers 45 | |
| 9/11/2010 | Texas A&M-Kingsville Javelinas 20 @ East Central 7 | † |
| 9/18/2010 | East Central 7 @ Abilene Christian Wildcats 47 | † |
| 9/25/2010 | Southwestern Oklahoma State Bulldogs 0 @ East Central 23 | † |
| 10/2/2010 | East Central 28 @ Central Oklahoma Bronchos 31 | † |
| 10/9/2010 | Incarnate Word Cardinals 27 @ East Central 13 | † |
| 10/16/2010 | Eastern New Mexico Greyhounds 19 @ East Central 22 | † |
| 10/23/2010 | East Central 20 @ Southeastern Oklahoma State Savage Storm 19 | † |
| 10/30/2010 | Northeastern State Riverhawks 21 @ East Central 48 | † |
| 11/6/2010 | East Central 36 @ Texas A&M-Commerce Lions 33 | † |
| 11/13/2010 | East Central 21 @ West Texas A&M Buffaloes 52 | † |