| 9/4/2010 | Eastern New Mexico Greyhounds 38 @ Angelo State 41 | † |
| 9/11/2010 | Angelo State 31 vs Texas A&M-Commerce Lions 10 (Dallas TX) | † |
| 9/25/2010 | West Texas A&M Buffaloes 37 @ Angelo State 27 | † |
| 10/2/2010 | Angelo State 34 @ Tarleton State Texans 37 | † |
| 10/9/2010 | Texas A&M-Kingsville Javelinas 28 @ Angelo State 21 | † |
| 10/16/2010 | Angelo State 21 @ Midwestern State Mustangs 35 | † |
| 10/23/2010 | Incarnate Word Cardinals 17 @ Angelo State 61 | † |
| 10/30/2010 | Angelo State 20 @ Abilene Christian Wildcats 33 | † |
| 11/6/2010 | Angelo State 40 @ Southeastern Oklahoma State Savage Storm 33 | † |
| 11/13/2010 | Central Oklahoma Bronchos 35 @ Angelo State 49 | † |