| 9/4/2010 | Lock Haven 6 @ VMI Keydets 48 | |
| 9/11/2010 | Lock Haven 21 @ Millersville Marauders 35 | † |
| 9/18/2010 | Kutztown Golden Bears 38 @ Lock Haven 13 | † |
| 9/25/2010 | Lock Haven 0 @ Mercyhurst Lakers 41 | † |
| 10/2/2010 | Lock Haven 0 @ California PA Vulcans 58 | † |
| 10/9/2010 | Clarion Golden Eagles 49 @ Lock Haven 6 | † |
| 10/16/2010 | Gannon Golden Knights 42 @ Lock Haven 7 | † |
| 10/23/2010 | Lock Haven 14 @ Slippery Rock Rockets 56 | † |
| 10/30/2010 | Edinboro Scots 30 @ Lock Haven 22 | † |
| 11/6/2010 | Lock Haven 31 @ Indiana PA Crimson Hawks 63 | † |
| 11/13/2010 | Bloomsburg Huskies 41 @ Lock Haven 17 | † |