| 9/4/2010 | California PA 42 @ Saginaw Valley State Cardinals 41 1OT | |
| 9/11/2010 | California PA 40 @ C W Post Pioneers 13 | † |
| 9/18/2010 | East Stroudsburg Warriors 20 @ California PA 45 | † |
| 9/25/2010 | California PA 24 @ Clarion Golden Eagles 9 | † |
| 10/2/2010 | Lock Haven Bald Eagles 0 @ California PA 58 | † |
| 10/9/2010 | California PA 34 @ Gannon Golden Knights 7 | † |
| 10/16/2010 | Slippery Rock Rockets 3 @ California PA 28 | † |
| 10/23/2010 | California PA 21 @ Mercyhurst Lakers 31 | † |
| 10/30/2010 | Indiana PA Crimson Hawks 15 @ California PA 18 1OT | † |
| 11/6/2010 | California PA 24 @ Edinboro Scots 0 | † |
| 11/13/2010 | Cheyney Wolves 6 @ California PA 57 | † |
| 11/20/2010 | Bloomsburg Huskies 28 @ California PA 26 | † |