| 9/2/2010 | Merrimack Warriors 26 @ Slippery Rock 45 | |
| 9/11/2010 | Slippery Rock 30 @ Cheyney Wolves 0 | † |
| 9/18/2010 | West Chester Golden Rams 27 @ Slippery Rock 33 | † |
| 9/25/2010 | Slippery Rock 0 @ Indiana PA Crimson Hawks 17 | † |
| 10/2/2010 | Slippery Rock 16 @ Clarion Golden Eagles 13 | † |
| 10/9/2010 | Edinboro Scots 14 @ Slippery Rock 28 | † |
| 10/16/2010 | Slippery Rock 3 @ California PA Vulcans 28 | † |
| 10/23/2010 | Lock Haven Bald Eagles 14 @ Slippery Rock 56 | † |
| 10/30/2010 | Slippery Rock 13 @ Mercyhurst Lakers 21 | † |
| 11/6/2010 | Gannon Golden Knights 24 @ Slippery Rock 20 | † |
| 11/13/2010 | C W Post Pioneers 42 @ Slippery Rock 38 | † |