| 9/2/2010 | Lake Erie Storm 20 @ Gannon 26 | |
| 9/11/2010 | Gannon 22 @ Shippensburg Red Raiders 19 | † |
| 9/18/2010 | Gannon 26 @ Millersville Marauders 29 | † |
| 9/25/2010 | Gannon 0 @ Edinboro Scots 13 | † |
| 10/2/2010 | Mercyhurst Lakers 10 @ Gannon 14 | † |
| 10/9/2010 | California PA Vulcans 34 @ Gannon 7 | † |
| 10/16/2010 | Gannon 42 @ Lock Haven Bald Eagles 7 | † |
| 10/23/2010 | Indiana PA Crimson Hawks 17 @ Gannon 45 | † |
| 10/30/2010 | Clarion Golden Eagles 11 @ Gannon 10 | † |
| 11/6/2010 | Gannon 24 @ Slippery Rock Rockets 20 | † |
| 11/13/2010 | Kutztown Golden Bears 27 @ Gannon 24 | † |