| 9/2/2010 | Lake Erie 20 @ Gannon Golden Knights 26 | |
| 9/11/2010 | Michigan Tech Huskies 42 @ Lake Erie 13 | † |
| 9/18/2010 | Lake Erie 17 @ Saginaw Valley State Cardinals 49 | † |
| 9/25/2010 | Lake Erie 37 @ Hillsdale Chargers 42 | † |
| 10/2/2010 | Ferris State Bulldogs 22 @ Lake Erie 12 | † |
| 10/9/2010 | Wayne State MI Warriors 28 @ Lake Erie 16 | † |
| 10/16/2010 | Lake Erie 23 @ Grand Valley State Lakers 57 | † |
| 10/23/2010 | Lake Erie 48 @ Findlay Oilers 45 | † |
| 10/30/2010 | Ohio Dominican Panthers 15 @ Lake Erie 30 | † |
| 11/6/2010 | Tiffin Dragons 27 @ Lake Erie 31 | † |
| 11/13/2010 | Lake Erie 17 @ Ashland Eagles 87 | † |