| 9/4/2010 | Assumption Greyhounds 33 @ Millersville 28 | |
| 9/11/2010 | Lock Haven Bald Eagles 21 @ Millersville 35 | † |
| 9/18/2010 | Gannon Golden Knights 26 @ Millersville 29 | † |
| 9/25/2010 | Bloomsburg Huskies 44 @ Millersville 7 | † |
| 10/2/2010 | Cheyney Wolves 20 @ Millersville 17 | † |
| 10/9/2010 | Millersville 21 @ C W Post Pioneers 49 | † |
| 10/16/2010 | Millersville 28 @ Kutztown Golden Bears 38 | † |
| 10/23/2010 | East Stroudsburg Warriors 65 @ Millersville 14 | † |
| 10/30/2010 | Millersville 14 @ Shippensburg Red Raiders 19 | † |
| 11/6/2010 | Millersville 14 @ West Chester Golden Rams 45 | † |
| 11/13/2010 | Millersville 10 @ Clarion Golden Eagles 49 | † |