| 9/4/2010 | North Greenville Crusaders 31 @ Charleston Southern 41 | |
| 9/11/2010 | Wofford Terriers 34 @ Charleston Southern 23 | |
| 9/18/2010 | Mars Hill Lions 14 @ Charleston Southern 28 | |
| 9/25/2010 | Charleston Southern 7 @ Hawaii Warriors 66 | |
| 10/9/2010 | Charleston Southern 20 @ Liberty Flames 44 | † |
| 10/16/2010 | Gardner-Webb Runnin' Bulldogs 35 @ Charleston Southern 25 | † |
| 10/23/2010 | VMI Keydets 34 @ Charleston Southern 16 | † |
| 10/30/2010 | Charleston Southern 21 @ Stony Brook Seawolves 41 | † |
| 11/6/2010 | Charleston Southern 21 @ Kentucky Wildcats 49 | |
| 11/13/2010 | Presbyterian Blue Hose 39 @ Charleston Southern 42 | † |
| 11/20/2010 | Charleston Southern 3 @ Coastal Carolina Chanticleers 70 | † |