| 9/4/2010 | Stony Brook 14 @ South Florida Bulls 59 | |
| 9/11/2010 | American Int'l Yellow Jackets 14 @ Stony Brook 31 | |
| 9/18/2010 | Stony Brook 30 @ Brown Bears 33 | |
| 9/25/2010 | Massachusetts Minutemen 26 @ Stony Brook 21 | |
| 10/9/2010 | VMI Keydets 9 @ Stony Brook 27 | † |
| 10/16/2010 | Stony Brook 21 @ Lafayette Leopards 28 | |
| 10/23/2010 | Stony Brook 38 @ Coastal Carolina Chanticleers 28 | † |
| 10/30/2010 | Charleston Southern Buccaneers 21 @ Stony Brook 41 | † |
| 11/6/2010 | Stony Brook 37 @ Presbyterian Blue Hose 7 | † |
| 11/13/2010 | Gardner-Webb Runnin' Bulldogs 3 @ Stony Brook 55 | † |
| 11/20/2010 | Stony Brook 28 @ Liberty Flames 54 | † |