| 9/4/2010 | Colorado State Rams 3 vs Colorado 24 (Denver CO) | |
| 9/11/2010 | Colorado 7 @ California Golden Bears 52 | |
| 9/18/2010 | Hawaii Warriors 13 @ Colorado 31 | |
| 10/2/2010 | Georgia Bulldogs 27 @ Colorado 29 | |
| 10/9/2010 | Colorado 0 @ Missouri Tigers 26 | † |
| 10/16/2010 | Baylor Bears 31 @ Colorado 25 | † |
| 10/23/2010 | Texas Tech Red Raiders 27 @ Colorado 24 | † |
| 10/30/2010 | Colorado 10 @ Oklahoma Sooners 43 | † |
| 11/6/2010 | Colorado 45 @ Kansas Jayhawks 52 | † |
| 11/13/2010 | Iowa State Cyclones 14 @ Colorado 34 | † |
| 11/20/2010 | Kansas State Wildcats 36 @ Colorado 44 | † |
| 11/26/2010 | Colorado 17 @ Nebraska Cornhuskers 45 | † |