| 9/5/2010 | Texas Southern 14 @ Prairie View Panthers 16 | † |
| 9/11/2010 | Texas Southern 3 @ Connecticut Huskies 62 | |
| 9/18/2010 | Alabama A&M Bulldogs 9 @ Texas Southern 32 | † |
| 9/25/2010 | Texas Southern 14 vs Tuskegee Golden Tigers 21 (Mobile AL) | |
| 10/2/2010 | Texas Southern 21 @ Alabama State Hornets 7 | † |
| 10/9/2010 | Texas Southern 30 @ Alcorn State Braves 20 | † |
| 10/23/2010 | Jackson State Tigers 18 @ Texas Southern 21 | † |
| 10/30/2010 | Mississippi Valley State Delta Devils 7 @ Texas Southern 38 | † |
| 11/6/2010 | Texas Southern 54 @ Southern Jaquars 7 | † |
| 11/11/2010 | Grambling Tigers 34 @ Texas Southern 41 1OT | † |
| 11/20/2010 | Ark Pine Bluff Golden Lions 13 @ Texas Southern 20 | † |
| 12/11/2010 | Alabama State Hornets 6 vs Texas Southern 11 (Birmingham AL) | † |