| 8/28/2010 | Southern Nazarene @ Eastern New Mexico | |
| 8/28/2010 | Bacone @ Haskell | |
| 8/28/2010 | Langston @ Incarnate Word | |
| 8/28/2010 | Belhaven @ Texas College | |
| 9/2/2010 | Texas College @ Oauchita | |
| 9/4/2010 | Langston @ Alcorn State | |
| 9/4/2010 | McMurry @ Bacone | |
| 9/4/2010 | Northwestern Oklahoma State @ Colorado State -Pueblo | |
| 9/4/2010 | St Mary KS @ Southern Nazarene | |
| 9/4/2010 | Austin @ Southwestern Assemblies of God | |
| 9/11/2010 | Southern Nazarene @ Haskell | |
| 9/11/2010 | Southwestern Assemblies of God @ Howard Payne | |
| 9/11/2010 | Texas College @ McMurry | |
| 9/11/2010 | Bacone @ Southwest Baptist | |
| 9/18/2010 | Southern Nazarene @ Bethel KS | |
| 9/18/2010 | Northwestern Oklahoma State @ South Dakota | |
| 9/18/2010 | Trinity Bible @ Southwestern Assemblies of God | |
| 9/25/2010 | Bacone @ Nicholls State | |
| 9/25/2010 | Texas College @ Northwestern Oklahoma State | † |
| 9/25/2010 | Langston @ Panhandle State | |
| 9/25/2010 | Southwest Baptist @ Southern Nazarene | |
| 10/2/2010 | Bacone @ Langston | † |
| 10/2/2010 | Northwestern Oklahoma State @ Missouri S&T | |
| 10/2/2010 | Southwestern Assemblies of God @ Southern Nazarene | † |
| 10/2/2010 | Concordia AL @ Texas College | |
| 10/9/2010 | Southwestern Assemblies of God @ Bacone | † |
| 10/9/2010 | Langston @ Lamar | |
| 10/9/2010 | Northwestern Oklahoma State @ Southern Nazarene | † |
| 10/16/2010 | Southwestern Assemblies of God @ Langston | † |
| 10/16/2010 | Bacone @ Northwestern Oklahoma State | † |
| 10/16/2010 | Texas College @ Panhandle State | |
| 10/23/2010 | Grand View @ Bacone | |
| 10/23/2010 | Northwestern Oklahoma State @ Langston | † |
| 10/23/2010 | Southwestern Assemblies of God @ Panhandle State | |
| 10/23/2010 | Southern Nazarene @ Texas College | † |
| 10/30/2010 | Texas College @ Bacone | † |
| 10/30/2010 | Lincoln MO @ Langston | |
| 10/30/2010 | Panhandle State @ Southern Nazarene | |
| 10/30/2010 | Northwestern Oklahoma State @ Southwestern Assemblies of God | † |
| 11/6/2010 | Southern Nazarene @ Bacone | † |
| 11/6/2010 | Panhandle State @ Northwestern Oklahoma State | |
| 11/6/2010 | Haskell @ Southwestern Assemblies of God | |
| 11/6/2010 | Langston @ Texas College | † |
| 11/13/2010 | Southern Oregon @ Northwestern Oklahoma State | |
| 11/13/2010 | Bacone @ Panhandle State | |
| 11/13/2010 | Langston @ Southern Nazarene | † |
| 11/13/2010 | Texas College @ Southwestern Assemblies of God | † |