| 8/28/2010 | Colorado State -Pueblo 23 @ Panhandle State Aggies 14 | |
| 9/4/2010 | Northwestern Oklahoma State Rangers 13 @ Colorado State -Pueblo 55 | |
| 9/18/2010 | Adams State Grizzlies 10 @ Colorado State -Pueblo 27 | † |
| 9/25/2010 | Colorado State -Pueblo 49 @ Fort Lewis Skyhawks 14 | † |
| 10/2/2010 | Chadron State Eagles 30 @ Colorado State -Pueblo 33 | † |
| 10/9/2010 | Colorado State -Pueblo 16 @ Colorado Mines Orediggers 19 | † |
| 10/16/2010 | Nebraska-Kearney Lopers 38 @ Colorado State -Pueblo 24 | † |
| 10/23/2010 | Colorado State -Pueblo 26 @ Mesa State Mavericks 14 | † |
| 10/30/2010 | New Mexico Highlands Cowboys 0 @ Colorado State -Pueblo 66 | † |
| 11/6/2010 | Colorado State -Pueblo 37 @ Western State Mountaineers 3 | † |
| 11/13/2010 | Colorado State -Pueblo 45 @ Western New Mexico Mustangs 17 | † |