| 9/4/2010 | McMurry 41 @ Bacone Warriors 6 | |
| 9/11/2010 | Texas College Steers 0 @ McMurry 64 | |
| 9/18/2010 | Mary Hardin-Baylor Crusaders 43 @ McMurry 31 | † |
| 9/25/2010 | McMurry 21 @ East Texas Baptist Tigers 23 | † |
| 10/2/2010 | Howard Payne Yellow Jackets 19 @ McMurry 51 | † |
| 10/9/2010 | McMurry 35 @ Sul Ross State Lobos 12 | † |
| 10/16/2010 | Texas Lutheran Bulldogs 14 @ McMurry 63 | † |
| 10/30/2010 | McMurry 13 @ Hardin-Simmons Cowboys 34 | † |
| 11/6/2010 | Louisiana College Wildcats 35 @ McMurry 32 | † |
| 11/13/2010 | McMurry 28 @ Mississippi College Choctaws 17 | † |