| 9/4/2010 | St Mary KS 17 @ Southern Nazarene Crimson Storm 63 | |
| 9/11/2010 | Bethany KS Terrible Swedes 51 @ St Mary KS 27 | † |
| 9/18/2010 | St Mary KS 17 @ Kansas Wesleyan Coyotes 59 | † |
| 9/25/2010 | Southwestern Moundbuilders 43 @ St Mary KS 21 | † |
| 10/9/2010 | St Mary KS 24 @ McPherson Bulldogs 73 | † |
| 10/16/2010 | Bethel KS Threshers 26 @ St Mary KS 42 | † |
| 10/23/2010 | St Mary KS 16 @ Ottawa Braves 34 | † |
| 10/30/2010 | Friends Falcons 35 @ St Mary KS 38 | † |
| 11/6/2010 | Sterling Warriors 21 @ St Mary KS 13 | † |
| 11/13/2010 | St Mary KS 7 @ Tabor Bluejays 27 | † |