| 8/28/2010 | Black Hills State Yellow Jackets 0 @ Grand View 28 | |
| 9/11/2010 | Grand View 10 @ St Francis IL Fighting Saints 17 | † |
| 9/18/2010 | Marian IN Knights 17 @ Grand View 7 | † |
| 9/25/2010 | Waldorf Warriors 0 @ Grand View 70 | † |
| 10/2/2010 | Grand View 7 @ William Penn Statesmen 38 | † |
| 10/9/2010 | Quincy Hawks 14 @ Grand View 41 | † |
| 10/23/2010 | Grand View 21 @ Bacone Warriors 18 | |
| 10/30/2010 | Iowa Wesleyan Tigers 6 @ Grand View 73 | † |
| 11/6/2010 | Grand View 20 @ Saint Ambrose Bees 17 | † |
| 11/13/2010 | Grand View 17 @ McKendree Bearcats 20 | † |