| 9/4/2010 | Howard Payne 34 @ Trinity TX Tigers 40 2OT | |
| 9/11/2010 | Southwestern Assemblies of God Lions 7 @ Howard Payne 32 | |
| 9/18/2010 | Howard Payne 30 @ Sul Ross State Lobos 37 | † |
| 9/25/2010 | Texas Lutheran Bulldogs 17 @ Howard Payne 39 | † |
| 10/2/2010 | Howard Payne 19 @ McMurry 51 | † |
| 10/9/2010 | Hardin-Simmons Cowboys 56 @ Howard Payne 0 | † |
| 10/16/2010 | Howard Payne 28 @ Louisiana College Wildcats 62 | † |
| 10/23/2010 | Mississippi College Choctaws 42 @ Howard Payne 27 | † |
| 10/30/2010 | Howard Payne 3 @ Mary Hardin-Baylor Crusaders 45 | † |
| 11/6/2010 | East Texas Baptist Tigers 24 @ Howard Payne 0 | † |