| 9/1/2022 | Wisconsin-Platteville | 13 | at | Michigan Tech | 23 | @ GLIAC (D2) | ||
| 9/3/2022 | Wisconsin-River Falls | 63 | at | Elmhurst | 0 | @ CCIW | ||
| Wisconsin-Whitewater | 10 | at | St John's MN | 24 | @ MIA | |||
| Loras | 27 | at | Wisconsin-Eau Claire | 30 | ARC | |||
| Dakota State | 7 | at | Wisconsin-La Crosse | 42 | NSAA (NAIA) | |||
| East Texas Baptist | 13 | at | Wisconsin-Oshkosh | 52 | ASWC | |||
| Mayville State | 31 | at | Wisconsin-Stevens Point | 24 | NSAA (NAIA) | |||
| 9/10/2022 | Wisconsin-Eau Claire | 13 | at | Central IA | 31 | @ ARC | ||
| Wisconsin-La Crosse | 30 | at | Dubuque | 3 | @ ARC | |||
| Wisconsin-Oshkosh | 10 | at | Northern Michigan | 13 | @ GLIAC (D2) | |||
| Wisconsin-River Falls | 34 | at | St John's MN | 37 | @ MIA | |||
| Wisconsin-Stevens Point | 14 | at | St Norbert | 21 | @ NAC | |||
| Bethel MN | 7 | at | Wisconsin-Platteville | 10 | MIA | |||
| Mary Hardin-Baylor | 24 | at | Wisconsin-Whitewater | 28 | ASWC | |||
| Wisconsin-Stout | 0 | at | Wartburg | 27 | @ ARC | |||
| 9/17/2022 | Wisconsin-Whitewater | 17 | at | Berry | 3 | @ SAA | ||
| Wisconsin-Stout | 28 | at | Gustavus Adolphus | 25 | @ MIA | |||
| Wisconsin-Oshkosh | 41 | at | Millsaps | 17 | @ SAA | |||
| Hardin-Simmons | 41 | at | Wisconsin-Platteville | 0 | ASWC | |||
| Northwestern MN | 27 | at | Wisconsin-River Falls | 63 | UMWAC | |||
| Simpson | 14 | at | Wisconsin-Stevens Point | 35 | ARC | |||
| Wisconsin-La Crosse | 28 | at | Wayne State MI | 21 | @ GLIAC (D2) | |||
| 9/24/2022 | Albion | 28 | at | Wisconsin-Eau Claire | 20 | MIAA | ||
| Crown | 6 | at | Wisconsin-Stout | 66 | UMWAC | |||
| 10/1/2022 | Wisconsin-Whitewater | 34 | at | Wisconsin-La Crosse | 31 | |||
| Wisconsin-Platteville | 7 | at | Wisconsin-Oshkosh | 46 | ||||
| Wisconsin-Stevens Point | 3 | at | Wisconsin-River Falls | 56 | ||||
| Wisconsin-Eau Claire | 29 | at | Wisconsin-Stout | 73 | ||||
| 10/8/2022 | Wisconsin-Whitewater | 45 | at | Wisconsin-Eau Claire | 24 | |||
| Wisconsin-Oshkosh | 24 | at | Wisconsin-River Falls | 27 | ||||
| Wisconsin-Platteville | 31 | at | Wisconsin-Stevens Point | 3 | ||||
| Wisconsin-La Crosse | 42 | at | Wisconsin-Stout | 21 | ||||
| 10/14/2022 | Wisconsin-Oshkosh | 3 | at | Wisconsin-Whitewater | 17 | |||
| 10/15/2022 | Wisconsin-La Crosse | 51 | at | Wisconsin-Eau Claire | 21 | |||
| Wisconsin-River Falls | 14 | at | Wisconsin-Platteville | 21 | ||||
| Wisconsin-Stout | 55 | at | Wisconsin-Stevens Point | 0 | ||||
| 10/22/2022 | Wisconsin-Stevens Point | 13 | at | Wisconsin-La Crosse | 55 | |||
| Wisconsin-Stout | 14 | at | Wisconsin-Oshkosh | 19 | ||||
| Wisconsin-Whitewater | 13 | at | Wisconsin-Platteville | 17 | ||||
| Wisconsin-Eau Claire | 6 | at | Wisconsin-River Falls | 63 | ||||
| 10/29/2022 | Wisconsin-Stevens Point | 26 | at | Wisconsin-Eau Claire | 48 | |||
| Wisconsin-La Crosse | 38 | at | Wisconsin-Oshkosh | 35 | ||||
| Wisconsin-Platteville | 22 | at | Wisconsin-Stout | 24 | 3OT | |||
| Wisconsin-River Falls | 27 | at | Wisconsin-Whitewater | 30 | ||||
| 11/5/2022 | Wisconsin-River Falls | 17 | at | Wisconsin-La Crosse | 24 | |||
| Wisconsin-Eau Claire | 14 | at | Wisconsin-Platteville | 38 | ||||
| Wisconsin-Oshkosh | 45 | at | Wisconsin-Stevens Point | 0 | ||||
| Wisconsin-Whitewater | 16 | at | Wisconsin-Stout | 7 | ||||
| 11/12/2022 | Wisconsin-Oshkosh | 61 | at | Wisconsin-Eau Claire | 0 | |||
| Wisconsin-Platteville | 10 | at | Wisconsin-La Crosse | 31 | ||||
| Wisconsin-Stout | 34 | at | Wisconsin-River Falls | 35 | ||||
| Wisconsin-Stevens Point | 10 | at | Wisconsin-Whitewater | 79 | ||||
| 11/19/2022 | Aurora | 33 | at | Wisconsin-Whitewater | 28 | D3 Championship Round 1 | NAC | |
| Wisconsin-La Crosse | 6 | at | Wartburg | 14 | D3 Championship Round 1 | @ ARC | ||
| Wisconsin-River Falls | 31 | vs | Washington U | 24 | Isthmus Bowl - Madison WI | vs CCIW |