| 9/3/2022 | Wayne State MI | 10 | at | Slippery Rock (10-3) | 42 | at PSAC | ||
| 9/10/2022 | Shaw (4-6) | 22 | at | Wayne State MI | 30 | CIAA | ||
| 9/17/2022 | Wisconsin-La Crosse (9-2) | 28 | at | Wayne State MI | 21 | WIAC (D3) | ||
| 9/24/2022 | Grand Valley State (12-1,7-1) | 48 | at | Wayne State MI | 9 | |||
| 10/1/2022 | Northern Michigan (4-7,1-6) | 37 | at | Wayne State MI | 30 | |||
| 10/8/2022 | Wayne State MI | 34 | at | Michigan Tech (4-7,2-5) | 35 | |||
| 10/15/2022 | Wayne State MI | 43 | at | Davenport (8-3,5-3) | 47 | |||
| 10/22/2022 | Saginaw Valley State (8-3,4-3) | 21 | at | Wayne State MI | 14 | |||
| 11/5/2022 | Wayne State MI | 14 | at | Grand Valley State (12-1,7-1) | 42 | |||
| 11/12/2022 | Ferris State (14-1,7-1) | 40 | at | Wayne State MI | 14 |
| vs Wayne State MI | vs Other Opponents | Wayne State MI compared to OOs | |
| Record: | 9-1 | 74-33 | |
| Points Scored: | 36.20 | 31.27 | -4.93 |
| Points Allowed: | 21.90 | 19.54 | 2.36 |
| Margin: | 14.30 | 11.73 | -2.57 |
| Total Points: | 58.10 | 50.81 | 7.29 |