| 8/27/2022 | Roosevelt (7-3) | 55 | at | Mayville State | 14 | MSFA | ||
| 9/3/2022 | Mayville State | 31 | at | Wisconsin-Stevens Point (1-9) | 24 | at WIAC | ||
| 9/10/2022 | Nebraska Wesleyan (1-9) | 48 | at | Mayville State | 55 | OT | ARC (D3) | |
| 9/17/2022 | Presentation (3-8,2-6) | 17 | at | Mayville State | 28 | |||
| 9/24/2022 | Mayville State | 14 | at | Dickinson State (8-3,8-0) | 48 | |||
| 10/1/2022 | Mayville State | 38 | at | Iowa Wesleyan (4-7,2-5) | 42 | |||
| 10/8/2022 | Waldorf (7-4,4-3) | 28 | at | Mayville State | 21 | |||
| 10/22/2022 | Dakota State (6-4,5-3) | 38 | at | Mayville State | 24 | |||
| 10/29/2022 | Mayville State | 0 | at | Presentation (3-8,2-6) | 21 | |||
| 11/5/2022 | Dickinson State (8-3,8-0) | 58 | at | Mayville State | 7 | |||
| 11/12/2022 | Valley City State (5-5,5-3) | 48 | vs | Mayville State | 40 | Fargo ND |
| vs Mayville State | vs Other Opponents | Mayville State compared to OOs | |
| Record: | 8-3 | 42-59 | |
| Points Scored: | 38.82 | 22.79 | -16.03 |
| Points Allowed: | 24.73 | 27.18 | -2.45 |
| Margin: | 14.09 | -4.39 | -18.48 |
| Total Points: | 63.55 | 49.97 | 13.58 |