| 9/1/2022 | Belhaven (8-2) | 49 | at | Millsaps | 21 | USASC | ||
| 9/10/2022 | Millsaps | 27 | at | McMurry (1-9) | 13 | at ASWC | ||
| 9/17/2022 | Wisconsin-Oshkosh (6-4) | 41 | at | Millsaps | 17 | WIAC | ||
| 10/1/2022 | Millsaps | 30 | at | Sewanee (2-8,0-7) | 27 | |||
| 10/8/2022 | Hendrix (3-7,2-5) | 28 | at | Millsaps | 34 | |||
| 10/15/2022 | Millsaps | 0 | at | Birmingham-Southern (7-3,5-2) | 28 | |||
| 10/22/2022 | Rhodes (5-5,3-4) | 31 | at | Millsaps | 7 | |||
| 10/29/2022 | Millsaps | 0 | at | Berry (7-3,5-2) | 56 | |||
| 11/5/2022 | Trinity TX (11-1,7-0) | 53 | at | Millsaps | 7 | |||
| 11/12/2022 | Millsaps | 3 | at | Centre (6-4,4-3) | 57 |
| vs Millsaps | vs Other Opponents | Millsaps compared to OOs | |
| Record: | 7-3 | 49-43 | |
| Points Scored: | 38.30 | 25.86 | -12.44 |
| Points Allowed: | 14.60 | 21.72 | -7.12 |
| Margin: | 23.70 | 4.14 | -19.56 |
| Total Points: | 52.90 | 47.58 | 5.32 |