| 8/25/2022 | Dakota Wesleyan (2-9) | 19 | at | Dakota State | 29 | GPAC | ||
| 9/3/2022 | Dakota State | 7 | at | Wisconsin-La Crosse (9-2) | 42 | at WIAC | ||
| 9/17/2022 | Dakota State | 17 | at | Waldorf (7-4,4-3) | 42 | |||
| 9/24/2022 | Iowa Wesleyan (4-7,2-5) | 7 | at | Dakota State | 24 | |||
| 10/1/2022 | Dickinson State (8-3,8-0) | 27 | at | Dakota State | 7 | |||
| 10/8/2022 | Dakota State | 31 | at | Valley City State (5-5,5-3) | 17 | |||
| 10/15/2022 | Presentation (3-8,2-6) | 21 | at | Dakota State | 19 | |||
| 10/22/2022 | Dakota State | 38 | at | Mayville State (3-8,1-7) | 24 | |||
| 10/29/2022 | Dakota State | 12 | at | Iowa Wesleyan (4-7,2-5) | 6 | |||
| 11/12/2022 | Waldorf (7-4,4-3) | 0 | at | Dakota State | 13 |
| vs Dakota State | vs Other Opponents | Dakota State compared to OOs | |
| Record: | 4-6 | 47-48 | |
| Points Scored: | 20.50 | 25.75 | 5.25 |
| Points Allowed: | 19.70 | 26.13 | -6.43 |
| Margin: | 0.80 | -0.38 | -1.18 |
| Total Points: | 40.20 | 51.88 | -11.68 |